NAPTHALENE IS SO OVER

I'm seriously fucking peeved about how few synthetic cannabinoids incorporate a 2-methoxyphenyl moiety. Admittedly, JWH-250 is kind of boring but the same holds true for JWH-018, JWH-081, and JWH-200. JWH-073 is the only one of these compounds which warrants (calculatedly) risking ones health - as it is truly a powerful psychedelic catalyst which surpasses Δ9-THC in every possible way - if not for that pesky (putative) carcinogenic metabolite.

I have heard well informed people say that they think, in terms of carcinogenicity, the napthalene moiety is a red herring, but why? If napthalene is not to blame then what is? Regardless, when one exchanges a 2-methoxyphenyl for napthalene the decrease in potency and binding at CB1 is modest enough that there is really no reason to continue using and selling these naphthyl compounds. In terms of subjective effects the N-butyl compounds like JWH-073 are superior to the more potent N-pentyls - so what about N-butyl JWH-250? I'm sure Huffman has synthed it but I can't look up its numerical designation right now, what I do know is that it has never been sold. It would be only a hair less potent than JWH-073, the same goes for the WIN55212-x compounds which are unexplored and fertile territory and as far as I can tell have never undergone 3-methoxyphenyl substitution.

I wish there were more work done to elucidate the nuanced effects of these cannabinoids - sure affinity at CB1 is an important measure of potency but why are certain cannabinoids more colorful - or psychedelic - or stimulating? As technology stands such tests would require human consumption and a cannabinoid version of Pihkal would probably be very (very) redundant. But now that im getting really into the SAR of CB1 agonists I'm realizing what an insane ligand whore that receptor really is - there is no hope in creating tests to screen for them all - this is only the beginning!!!

Ah, so much work to be done...

NBOMe-A-GO-GO

It has been hypothesized that all the worlds psychedelic tryptamines and phenethylamines were synthesized en masse and then divvied up globally sometime around 2002. It has also been hypothesized that forensic chemical fingerprinting could be used analyze trace impurities and prove this now - or in the near future. Lastly, It has been predicted that these global stores of phenethylamines with a primary amine will soon undergo the facile conversion to their secondary amine 2-methoxybenzylated counterparts.

The implications of this are obvious.

MARINA ABRAMOVIC

I just went to the Marina Abramovic retrospective at MOMA, I was especially interested in a 1974 performance called RYTHM 2, which was described as follows:

I use my body for anexperimentI take the medicationused in hospitals for thetreatment of acute catatoniaand schizophrenia, and putmy body in an unpredictable
state
Performance

First part
Facing the audience, I take the first medication.This medication is given to patients who suffer from catatoniato force them to change the position of their bodies.Shortly after taking the medication, my muscles begin to
violently contract, until completely loosing control. 
First part: 15 minutes

There was a second part to the pharmacological performance but I did not transcribe the description, it entailed ingesting (what sounded like) a standard first generation antipsychotic like thorazine. Part one is much more interesting and mysterious, there was a photo of her in (what appeared to be) bruxismic agony, but I have absolutely no knowledge of the Yugoslavian pharmacopeia in the mid 70s (1974). As far as I know it could have been strychnine - but its seems odd for them to treat catatonia with some kind of pro-epileptic spasmodic drug, anti-epileptics are used for that purpose today. Does anyone have an idea of what the drug used in the first part of RYTHM 2 could have been?


I swear I've read that, as an alternative to ECT, seizures are induced chemically instead of electrically in europe - but I cant find the source or names of the drugs used to induce a therapeutic seizure...

SOCRATIC DIALOG

Socrates: Tell me about the "40 Loads" event. How have you collected these loads? How have you prepared yourself for swallowing so much cum and what was the feeling after swallowing it?

Plato: Well, my boyfriend pretty much "secretly" froze 40 loads of cum over about 6 weeks and then told me he wanted to do a bukkake-style cumdrinking video. No facials, just me gulping down those 40 cum shots. At that time I had already drunk 10 loads at once and I knew that it was harder than it sounded. Anyway, he expected me to say no so he was thrilled to bits when I said that I'd do it. The ugly truth behind that video is, that I managed to keep the 40 loads down for about 20 maybe 30 minutes before I threw up. I was proud to have lasted that long :)

Socrates: Is there some change of cum-taste after being frozen?

Plato: Absolutely. I'd rather have it fresh from the tap than frozen. Cum loses all its gooey texture once you freeze it and flavor's affected as soon as the cum is exposed to air. It degrades rather quickly. Cum tastes best when it's warm and you can swallow it right away. It tends to go a little bitter right after it cools down and reacts with oxygen, I guess, I'm not a chemist. Don't get me wrong, I will drink thawed cum and I will lick cold cum off a plate or off the floor or whatever, it's just not as good then as it could be.

LEGAL DRUG TEEN RIPPED HIS SCROTUM OFF

ANTISCIENCE - BATAILLE & ICP

Philosophy will clip an Angel’s wings,

Conquer all mysteries by rule and line,

Empty the haunted air, and gnomed mine—

Unweave a rainbow, as it erewhile made

The tender-person’d Lamia melt into a shade.

- John Keats, 1884

Left to itself, free in the poorest sense of the word (where liberty is only impotence), inasmuch as its legacy as the first condition of existence was the task of dissipating and annihilating mythological phantasms, nothing could keep science from blindly emptying the universe of its human content. But it is possible to use it to limit its own movement and to situate beyond its own limits what it will never attain, that before which it becomes an unsuccessful effort and a vague, sterile being.

- Geroges Bataille, 1936

I see miracles all around me

Stop and look around, it’s all astounding

Water, fire, air and dirt

Fucking magnets, how do they work?

And I don’t wanna talk to a scientist


Y’all motherfuckers lyin, and gettin me pissed!

- Insane Clown Posse, 2010

SMOKEBATH

peter sutherland put together this incredible show which seems to feature everybody on the planet. there was also a book made out of it which i have not yet seen.

check out my contribution: