CONFORMATIONALLY CONSTRAINED TRYPTAMINE ANALOGS

What would happen if LSD and DMT explored "the erotic" and give birth to a child?

Conformationally constrained tryptamine analogs. Can we talk? Why was the last paper on this topic published in 1967? Why are we not all basking in the glory of 1,3,4,5-tetrahydrobenzoindoles? The above structure is a hybrid btw LSD and DMT, its affinity for the 5HT2a receptor is significantly less than that of LSD but a bit more than DMT, it may have oral activity, and it should be planar as heck! Well you know the world of speculative pharmacology is highly unsatisfying (total pharmacoblueballs) and all things must be tested in the human animal but wow - throw on an N,N-diethyl substituent, or a N-methyl,N-isopropyl sub and you're in business - you dig?

catch you on the flip side.