Alexander Shulgin's drew me this diagram toward the end of his life, due to his failing vision the molecule was almost a blind contour, which resulted in the diisopropylethylamine side chain being attached to the indole 2-position as opposed to the 3-position. Though I imagine this was drawn in error I can't help but see it as a clue, maybe a result of a subconscious interest in the 2-isotryptamines, a synthetically challenging and pharmacologically promising area.
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What would you say this is similar to? Do you have an expectation on possible effects?
Ketamine Acts fast to treat depression and its effects last - but how?
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In contrast to most antidepressant medications, which can take several weeks to reduce depressive symptoms, ketamine — a commonly used veterinary anesthetic — can lift a person out of deep depression within minutes of its administration, and its effects can last several weeks. Researchers have long-wondered how ketamine can both act quickly and be so long-lasting.
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Now, researchers led by Mark Rasenick, distinguished professor of physiology and psychiatry at the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine’s ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry.
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Two-thirds of participants in clinical studies who did not respond to traditional antidepressants experienced fast and lasting resolution of their depressive symptoms after being given ketamine intravenously, Rasenick explained. The effects of ketamine typically lasted about a week — much longer than would be expected with ketamine’s six-hour half-life in the body.
Rasenick and his colleagues used a cellular model system to investigate how ketamine acted.
In previous research, Rasenick and his colleagues showed that SSRIs — the most commonly prescribed class of antidepressants, which includes Prozac and Zoloft — work in the brain by moving molecules called G proteins off of “lipid rafts” on the cell membrane, where the G proteins are held inactive. G proteins produce cyclic AMP, which nerve cells need to signal properly. People with depression, Rasenick found, tend to have a greater proportion of their G proteins packed into these membrane patches, along with dampened brain cell signaling, which may contribute to symptoms of depression, including a feeling of overall numbness.
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O que está acontecendo? Eu sou novo nisso, descobri que descobri que é positivamente útil e me ajudou muito. Espero dar uma contribuição e ajudar outros clientes como o que me ajudou. Bom trabalho.
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