Thursday, January 28, 2010

CONFORMATIONALLY CONSTRAINED TRYPTAMINE ANALOGS

what happens when LSD and DMT explore "the erotic" and give birth to a child?

conformationally constrained tryptamine analogs, can we talk? i mean can we talk! why was the last paper on this topic published in 1967? why are we not all basking in the glory of 1,3,4,5-tetrahydrobenzoindoles? the above structure is a hybrid btw LSD and DMT, its affinity for the 5HT2a receptor is significantly less than that of LSD but a bit more than DMT, i would imagine that it is not broken down by MAO suggesting oral activity, and it should be planar as heck! well you know the world of speculative pharamcology is highly unsatisfying (total pharmacoblueballs) and all things must be tested in the human animal but wow - throw on a n,n-diethyl substituent, or a n-methyl,n-isopropyl sub and your in business - you dig?

catch you on the flip side.