Wednesday, December 30, 2015

5-Br-DMT REPORTS?


In 2013 I published a series of reports in Vice magazine on 5-Bromo-DMT, a sponge alkaloid with psychedelic activity in man. The potency was lower than DMT and the effect was less than spectacular, but the simple fact that the drug represented the first psychedelic isolated from the ocean (and only the ocean) made it fascinating. The article generated some modest discussion on drug forums and then interest faded away.

To my surprise and excitement, two years and seven months after the article's publication, 5-Br-DMT appeared for sale amongst the offerings of a research chemical vendor. I waited patiently for reports to appear on drug forums and Reddit but was only able to find a single report posted on October 30th by a user named Sporelock:
"I have tried this. It provided a thorough stoning effect, with the only visuals produced being colour saturation and mild waving or breathing, like a low dose of mushrooms or something, and that was at its most intense part. Its just nice an relaxing, and very smooth but light. This is not a breakthrough intensity experience like plain DMT or 5-MeO-DMT. I loaded around 50-65(?) mg into a pipe and shared it with two other friends, (this is a guess I didnt actually measure it because I knew its effects were very light and going too far is pretty difficult).Worth a try, and it doesn't exhaust you very much. You are totally functional and we were able to city bus down to a restaurant for a beer part way through the experience.......I was past the peak though and only had to talk while getting a beer. I didn't need to control my headspace around my friends at the bar though. Just a little extra focus while talking to the barkeep. Theres a minor headspace, but its manageable definitely.
...While its not super intense or overly active, it still is a DMT analogue. And all tryptamines have fucked up tolerance curves. Its like a once a week maximum thing to be honest. Im just assuming you smoke weed more than 1 time a week. plus weed will be far easier to find. It was nice to smoke weed and be on 5-br-dmt, but its just not feasible to always have it.
...If it combusts alot of the activity is lost, or so Ive heard. You need to get a crack pipe or an actualy vaporizer and hover your lighter under it until you see thin vapour forming and inhale those. Look online for proper use of a crack pipe."

I was unable to find additional reports and have no idea how many people have used this drug. Since the publication of the Vice article Jason Wallach and I have continued to study 5-Br-DMT and may write a followup piece. If you have used 5-Br-DMT please send me an email to tell me about your response, the more datapoints the better.

Wednesday, January 21, 2015

[2-(1H-indol-2-yl)ethyl]bis(propan-2-yl)amine; methanetetraide










Alexander Shulgin's drew me this diagram toward the end of his life, due to his failing vision the molecule was almost a blind contour, which resulted in the diisopropylethylamine side chain being attached to the indole 2-position as opposed to the 3-position. Though I imagine this was drawn in error I can't help but see it as a clue, maybe a result of a subconscious interest in the 2-isotryptamines, a synthetically challenging and pharmacologically promising area.