Saturday, December 3, 2011



Anonymous said...

Hi, there was a poorly translated interview a few pages back that mentioned you taking anti depressants. It could have been a joke that got lost in translation cause it said something about inheriting it from your dead dog? Anyway, do you take antidepressants? If so which ones do you take? Do you recommend them for treatment of depression? They're used by so many and a lot of people have moral issues with them or claim they just leave you numb. I have a lot of respect for you and would really like to know your opinion, thanks...

Hamilton Morris said...

Hey, treatment with SSRI antidepressants is definitely a polarizing issue, and there are a number of SSRI critics like David Healy (who I respect) that feel drugs like fluoxetine are not only ineffective but possibly dangerous because they may increase risk of suicide. There is also the issue of discontinuation syndrome, which is particularly pronounced in paroxetine users.

Plenty of studies suggest SSRI use has benefits like increasing hippocampal volume, promoting the release of BDNF, and, of course, relieving depression. Ultimately taking SSRIs is a personal choice, if they work for you that is great.

Keep in mind the distinction "antidepressant" is arbitrary with no pharmacological basis. Anything could be an antidepressant if it provides relief from depression. It was not very long ago that Ritalin and amphetamine were routinely prescribed for depression, in addition to "antidepressant" psychedelics like aET and aMT, both of which were once approved pharmaceuticals.

I have never taken SSRI antidepressants, though I have experimented with chemicals like tianeptine, selegiline, bupropion, and moclobemide all of which are or have been indicated for depression.

Check out the book Manufacturing Depression for a good discussion of this issue.

Hamilton Morris said...

I should also add that while the "an antidepressant is something that relieves depression" definition may sound obvious, it is actually not the only requirement of a successful pharmaceutical antidepressant. One of the main attributes of the SSRIs from a Big Pharma perspective is their extremely low acute toxicity i.e. if a depressed patient drinks a bottle of fluoxetine very little will happen, whereas imipramine users may not be so lucky. The MAOIs may be more effective but their numerous contraindications make psychiatrists squirm.

Anonymous said...

I'll definitely check it out, thanks so much.

Anonymous said...

i wonder where she is now

RaquelHenriques said...

Hey, I just want to thank you because you're my soundtrack for studying sessions.
I hope this doesn't sound creepy, but listening to you talking about drugs just makes programing easier. So thanks for helping me through college!

ScooterKPFT said...

LSD and liquor is a very unpredictable combination.

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