Sunday, August 25, 2013

MK-801 HISTORY?













Despite having been in gray-market use for almost twenty years, MK-801 is arguably the least common RC dissociative. It is so rare that I am not entirely sure how many of the reports on its qualitative effects (which are less than ten in number) are from users ingesting material diverted from legitimate bioscience suppliers or laboratories (in which context it is extremely common) relative to those acquiring the material from gray-market RC sources. Accounting for MK-801's extreme scarcity are a non-trivial four-step synthesis from an unusual precursor (5-dibenzosuberenone), its association with at least one fatal poisoning, its implication in the formation of Olney's lesions (which I am aware have never been observed in humans), and its general conception as a non-euphoric, Jacob's Ladder-ish amnesiogen. But recently Erowid published an extraordinarily detailed MK-801 experience report that presents what I feel is the most illuminating description of the drug's qualitative effects written thus far. The report (titled The Most Beautiful Lobotomy I Ever Had and written by a user named viscosity) incorporates some objective measurement of vital signs, multiple trials at escalating doses, and passing mention of use by the author's friends. Here is an excerpt:
I somehow am able to use the webcam on my computer and take many random video clips where I start recording only to forget what I wanted to say or why I even began recording in the first place. So I make some short 5 second comment about how I’m really far gone and just use undescriptive phrases like “What just happened?” “I’m not really sure” “I don’t know” and “Wow. Just Wow”. My ability to communicate verbally is pretty messed up as I’m stuttering, taking with a heavy speech impediment and keep loosing words in the middle of sentences. I can’t seem to convey in English what the drug feels like at all. It’s so intensely strange and surreal the words completely escape me....
In some videos I obviously have no clue what I’m doing or that I am even recording. I record myself eating something, then wander off camera only to come back at the computer to stare at it, trying to make sense of it, then wander off to mumble some incoherent gibberish off camera. At one point I cannot locate the trash can to throw a food container away for a good couple of minutes and am completely mystified as to where it had gone. It was actually only one and a half feet from its usual location but I could not remember that I had moved it there, and its new location was seemingly invisible to me despite it being directly in my field of vision. I’m not in a bad mood, but I am completely shot at this point and very confused. I even somehow manage to record a video of me watching a video of myself that I had just recorded of me watching myself on the video preview (that one was pretty funny to watch later. By the look on my face I seem to be kind of amused, yet absolutely bewildered and unable to process the sensory stimuli in front of me).
I'm posting this for two reasons: first it's simply an interesting report that counters the idea that euphoric effects of ketamine and other NMDA antagonists can only result from action at targets other than the NMDA receptor, and secondly because I am writing a review article about gray-market dissociative history and would very much like to collect reports from anyone who has self-experimented with MK-801 (also called dizocilpine) or who can provide me with historical information about RC vendors that have carried it in the past.

12 comments:

Wayne Wang said...

Hey Hamilton can you cite some sources you use regarding this drug and some of the more obscure psychedelics around? I am writing a book chapter on hallucinogenic substances and it would be awesome if you could help me. Thanks!

Hamilton Morris said...

A chapter for what book? Most of this information is going to be compiled in a review published in the journal Drug Testing & Analysis in the fall.

Wayne Wang said...

I am working on a book with a pharmacy professor at my university which aims to give people adequate information about the various effects of illicit substances so they can do it safely. Could you send me the link to the review once it is up?

Klein Bottles and other amenities said...

Look at section 3 of this paper, it talks about some differences in Ketamine and MK-801 effects,

https://www.jstage.jst.go.jp/article/jphs/120/2/120_12R08CP/_pdf

good luck with your research.

Wayne Wang said...

Thank you :)

Matt Wheeler said...
This comment has been removed by the author.
Chris Lee said...

Fascinating post. Reminds me of reports of datura in some respects.

Jopy fizzle said...

I take it you have investigated diphenidine? This compound is relatively new on the market and the reports show a surprising similarity to MK-801 in my opinion.

take care

Solipsis

Romain Romainpinpin said...

The structure really look like harmine

Steve Gill said...

Scary stuff....tgreatnblog BTW - cheers.

Steve Gill said...

Sheesh.....typo hell here ; ;^p

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